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Genome of near-extinct northern white rhino offers hope for reviving the species

  • Scientists mapped the complete genome of a northern white rhinoceros in 2025 using preserved cells from Angalifu, a male who died in 2014 at the San Diego Zoo Safari Park.
  • This effort continues a long-standing initiative that began in 2007, motivated by the critical situation of the northern white rhino, which now only has a pair of remaining females and lacks natural reproductive possibilities due to severe losses from poaching.
  • The research published in a leading scientific journal utilized state-of-the-art DNA sequencing and genome assembly methods to produce a high-quality reference genome, facilitating the examination of existing northern white rhinoceros stem cell lines.
  • Loring explained that without first creating this genome, they would have missed identifying a critical mutation in some stem cell lines that impacted more than 200 genes, including those related to reproduction and tumor suppression.
  • The genome serves as a crucial tool guiding efforts to produce healthy embryos via lab-grown sperm and eggs for implantation, potentially restoring this critically endangered species and aiding broader conservation.
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Rhino headed for extinction could be revived after genome breakthrough

Sudan, the world’s last male northern white rhino, died at a conservation centre in Kenya, aged 45, in 2018.

The rhino lay frozen in the sand, its glassy eyes open, its horn roughly cut off. Welcome to the South African school that trains forensic scientists who specialize in wildlife crime.

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Brisbane Times broke the news in Brisbane City, Australia on Wednesday, May 7, 2025.
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