Inhibiting Mycobacterium Tuberculosis CoaBC by Targeting an Allosteric Site

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium tuberculosis. The biosynthesis of CoA is performed in five steps, with the second and third steps being catalysed in the vast majority of prokaryotes, including M. tuberculosis, by a single bifuncti…

Sachem East High School reports tuberculosis case

A student was undergoing treatment for the infectious disease, the school said.