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Thousands of cancer cases could be prevented with more breast removal surgeries, study suggests

UNITED KINGDOM, JUL 24 – Research shows offering preventive mastectomy to women with 35% or higher breast cancer risk could prevent 11% of UK cases annually, about 6,500 women, study finds.

  • On 24 July 2025, researchers in the UK found thousands of breast cancer cases could be averted annually, study published in JAMA Oncology.
  • Professor Ranjit Manchanda defined a 35% risk threshold for offering RRM to women aged 30 to 55, noting UK women have an 11% lifetime breast cancer risk.
  • Analysis indicates significant impact and cost-effectiveness, with the economic evaluation study in JAMA Oncology concluding RRM appears cost-effective for women 30-55 with ≥35% lifetime risk.
  • It’s vital that choosing risk-reducing surgery remains a personal decision, Louise Grimsdell said, and unacceptably long waits must be tackled urgently.
  • Researchers suggest further evaluation, and current guidelines may require revision to reflect these findings.
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Medical Xpress broke the news in on Thursday, July 24, 2025.
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