Protective Exercise Responses in the Dentate Gyrus of Alzheimer’s Disease Mouse Model Revealed with Single-Nucleus RNA-Sequencing

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear. Here we used single-nucleus RNA sequencing (snRNA-seq) to dissect the response to exercise (free-wheel running) in the neurogenic stem-cell niche of the hippocampal dentate gyrus in male APP/PS1 transgenic AD model mice. Transcriptomic responses to exercise were distinct between wild-type and AD mice, …

Exercise Rewires Alzheimer’s-Affected Brain Cells

Using cutting-edge RNA sequencing, researchers mapped how exercise affects specific brain cell types in a model of Alzheimer’s disease. They found that physical activity alters gene activity in microglia and a newly identified type of astrocyte linked to blood vessels, which may protect memory.

Rewrite Protective exercise responses in the dentate gyrus of Alzheimer’s

Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear. Here we used single-nucleus RNA sequencing (snRNA-seq) to dissect the response to exercise (free-wheel running) in the neurogenic stem-cell niche of the hippocampal dentate gyrus in male APP/PS1 transgenic AD model mice. Transcriptomic responses to exercise were distinct between wild-type and AD mice, …