Knot A Problem: Mechanism Found For DNA Loop Control - Data Intelligence

Frog Egg Extracts Illuminate the Untangling Mechanism of DNA Knots

Research reveals how G-quadruplex DNA structures are untangled, highlighting a role for RNA in genome stability and potential cancer therapy strategies.

Knot A Problem: Mechanism Found For DNA Loop Control - Data Intelligence

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a knot. These knot-like conformations can play important roles in turning genes on or off. But if not untangled in time, they can harm our genome. Researchers in the group of Puck Knipscheer, PhD, at the Hubrecht Institute, in collaboration with scient…

Knot a Problem: Mechanism Found for DNA Loop Control

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a knot. These knot-like conformations can play important roles in turning genes on or off. But if not untangled in time, they can harm our genome. Researchers in the group of Puck Knipscheer, PhD, at the Hubrecht Institute, in collaboration with scient…

Rewrite Knot good: How cells untie DNA to protect the genome this news

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