Reward-related neurons drive risky decision-making differently in male and female rats

Reward-related neurons drive risky decision-making differently in male and female rats

Some people with psychiatric conditions, including addiction and attention deficit hyperactivity disorder, struggle to control their urges or make decisions under uncertainty. In a collaboration between the University of Cambridge and the University of British Columbia, Tristan Hynes and colleagues used rats to explore the role of a specific reward-related neuron population in shaping impulsivity and risky decision-making during a gambling task.

Brain Circuit Found to Shape Risk and Impulse Differently by Sex

Researchers exploring risky decision-making in rats found that a specific reward-related neural circuit influences impulsivity and risk-taking in complex ways that depend on timing and biological sex. Manipulating the circuit during the learning phase of a gambling task altered risky choices differently in males and females, while manipulation after learning affected motor impulsivity in both.