Researchers link genetic ancestry to severity of dengue fever
4 Articles
4 Articles
Researchers link genetic ancestry to severity of dengue fever
For the first time, the extreme variability in dengue fever has been linked to a biological mechanism, potentially opening doors to new treatments and vaccines for the most common mosquito-borne disease worldwide.
Dengue Severity Linked to Genetic Ancestry’s Influence on Immune Response
Researchers at the University of Pittsburgh, University of Pittsburgh Medical Center, and Instituto Aggeu Magalhães, have for the first time linked the extreme variability in severity of the mosquito-borne viral disease, dengue, between individuals, to the influence of genetic ancestry on inflammatory responses in the skin. The team exposed human skin explants from donors of European or African ancestry to dengue virus (DENV) and examined immune…
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