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RED-CRISPR doubles knock-in efficiency

Traditional CRISPR-Cas9 methods have revolutionized genetics, but large functional sections of DNA, called payloads, still cannot be inserted into the genome without compromising cell viability or creating unwanted effects. Standard Homology-Directed Repair (HDR) dramatically loses efficacy for payloads exceeding 1 kilobase, compromising cell viability and increasing off-target edits. The 1 kb problem CRISPR, which stands… The post RED-CRISPR do…
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Research & Development World broke the news in on Monday, December 15, 2025.
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