Reactivation of dormant regulatory T cells alleviates asthma symptoms in mice

Reactivation of dormant regulatory T cells alleviates asthma symptoms in mice

A collaborative effort among researchers at the Henan Academy of Innovations in Medical Science, Zhengzhou University, and Shenzhen University School of Medicine has provided the first proof-of-principle study demonstrating that targeting a receptor on the surface of anti-inflammatory regulatory T cells (Tregs) can restore their function and alleviate asthma in mice.

Targeting Dectin-1 Restores Regulatory T Cell Function in Asthma Models

A research collaboration between the Henan Academy of Innovations in Medical Science, Zhengzhou University, and Shenzhen University School of Medicine has identified a mechanism of regulatory T cell (Treg) dysfunction in allergic asthma and showed how to their activity. The study, published in Life Science Alliance, shows that Tregs in patients with allergic asthma enter a senescence-like, functionally impaired state, and that engaging the Decti…