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Rare Genetic Disorder Reveals How a ‘Biological Clock’ Drives Aging

The finding links the DNA methylation clock to earlier tissue decline and disease, and the team says the collaboration involved 76 researchers from seven countries.

  • Researchers led by the University of Edinburgh discovered Heyn-Sproul-Jackson syndrome , a rare genetic condition where cellular 'biological clocks' accelerate aging far faster than normal.
  • DNA methylation marks naturally accumulate over time as a 'biological clock' in every cell; in HESJAS patients, these markers occur at the same locations as normal aging but at a much quicker rate.
  • Accumulating marks impair adult stem cells crucial for tissue renewal, causing health issues typically seen in old age—osteoporosis, hair loss, and metabolic changes like diabetes—much earlier in HESJAS patients.
  • Published in Nature Genetics, the international study involved 76 researchers from seven countries, with study lead Professor Andrew Jackson emphasizing the importance of understanding this 'biological clock' for long-term health.
  • Future studies are planned to investigate how DNA methylation reduces tissue renewal and reverse these epigenetic changes, as experts believe the findings could support development of rejuvenation therapies for age-related diseases.
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Rare genetic disorder reveals how a ‘biological clock’ drives aging

The study identified a "biological clock" which ticks in every cell of the body.

·Chariton, United States
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News Medical broke the news in United States on Tuesday, June 30, 2026.
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