Rare cancer gene found in sperm donor sparks European regulatory concerns
- A sperm donor in Europe was identified as carrying a cancer-associated TP53 gene mutation linked to Li-Fraumeni syndrome, affecting children born in multiple countries over several years from 2008 to 2015.
- The discovery followed reports of 67 tested children from 46 families, with 23 carrying the variant and 10 diagnosed with childhood cancers like leukemia and lymphoma, prompting a multinational investigation.
- Researchers led by Dr. Edwige Kasper at Rouen University Hospital used population databases, prediction tools, and functional tests to assess the variant, coordinating with European genetic networks under GENTURIS.
- The donor began giving sperm before mosaicism detection techniques existed, while varying national laws limit births per donor from 10 in France to 15 in Germany and Denmark, highlighting regulatory fragmentation in Europe.
- This case has exposed cross-border regulatory gaps, underscoring calls for harmonized European or international oversight to limit donor offspring numbers and improve genetic risk management.
15 Articles
15 Articles
Sperm Donor with Dangerous Gene Mutation Fathered at Least 67 Children in Europe: Ten Have Cancer
At least 67 children spread across several European countries have been conceived with the sperm of a donor who appears to have a rare cancer-causing gene mutation. At least ten children have now been diagnosed with cancer, reports the British newspaper The Guardian.
Sperm Donor Spread Rare Cancer Gene – Doctors Demand New Limits
A sperm donor who fathered at least 67 children across Europe has been found to carry a rare, cancer-causing gene. Ten of the children have now been diagnosed with cancer. “We need to set a European limit on how many children a single donor can father,” Edwige Kasper, a biologist at Rouen University Hospital in France, told The Guardian.
How a Sperm Donor Has Transmitted a Cancer-Predisposing Gene to Dozens of Children in Europe
The man, who made his donation to a private sperm bank in Denmark, was carrying a variant promoting the occurrence of early cancers. He is responsible for at least 67 births, including at least 23 children affected by the genetic anomaly.
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