Potential ALS Mitochondrial Target Identified with CRISPR, scRNA-seq

Potential ALS Mitochondrial Target Identified with CRISPR, scRNA-seq

Eleven years after the Ice Bucket Challenge brought ALS into the public spotlight, the neurodegenerative disease is once again drawing scientific attention—this time through the lens of CRISPR and single-cell genomics. A new study published in Nature Communications, “Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS,” offers fresh insight into how ALS begins, long before …