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Pioneering cell therapy offers hope for advanced liver disease
The therapy reprograms immune cells to repair scarred livers, and 70% of treated patients avoided transplant after four years, researchers said.
- Researchers at the University of Edinburgh announced yesterday that a new cell therapy significantly reduces the need for liver transplants in advanced liver disease patients, with 70% of treated individuals remaining transplant-free after four years compared with 40% receiving standard care.
- Advanced liver scarring leaves patients with few options beyond transplantation, a treatment restricted by insufficient donor organs, with many patients dying while awaiting available livers.
- Macrophages extracted from patients' blood travel to the liver to break down scar tissue and reduce harmful inflammation, with no serious adverse events reported during the trial and treated patients experiencing zero transplants versus five in the standard care group.
- Pamela Healy, Chief Executive of the British Liver Trust, called the results 'real hope' for cirrhosis patients and said a treatment reducing transplant need would be 'truly life changing' for families facing this disease.
- Resolution Therapeutics, co-founded by Professor Stuart Forbes in 2020, is advancing the research with RTX001, a next-generation version being tested in the EMERALD clinical trial funded by the Medical Research Council and Chief Scientist Office.
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Macrophage cell therapy boosts four-year transplant-free survival in advanced cirrhosis
A new type of cell therapy shows promise as the first treatment for advanced liver disease, following results from a clinical trial. Patients with the condition who were treated with the cell therapy had a significantly lower risk of death or need for a liver transplant after four years compared with those who received standard medical care.
The IndependentReposted by 
perspectivemedia.com
perspectivemedia.comNew cell therapy offers ‘real hope’ for liver disease patients
Researchers hope the findings could reduce the need for liver transplants.
·London, United Kingdom
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Coverage Details
Total News Sources12
Leaning Left4Leaning Right0Center2Last UpdatedBias Distribution67% Left
Bias Distribution
- 67% of the sources lean Left
67% Left
L 67%
C 33%
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