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Pentose Phosphate Pathway Inhibition Metabolically Reprograms CD8+ T Cells and Disrupts CNS Autoimmunity
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Pentose Phosphate Pathway Inhibition Metabolically Reprograms CD8+ T Cells and Disrupts CNS Autoimmunity
Transcriptional profiling of central nervous system (CNS)-infiltrating CD8+ T cells in patients with multiple sclerosis indicated increased pentose phosphate pathway engagement, suggesting that this pathway is involved in CD8+ T cell-mediated injury of axons and neurons in the demyelinated CNS. [JCI Insight] Full ArticleGraphical Abstract
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