Pain-Sensing Neurons in the Gut Spark Inflammatory Immune Responses

Pain-sensing neurons in the gut spark inflammatory immune responses

Pain sensing neurons in the gut kindle inflammatory immune responses that cause allergies and asthma, according to a new study by Weill Cornell Medicine.

Pain-sensing neurons kick-start immune responses that drive allergies and asthma

Pain-sensing neurons in the gut kindle inflammatory immune responses that cause allergies and asthma, according to a new study by Weill Cornell Medicine. The findings, published in Nature, suggest that current drugs may not be as effective because they only address the immune component of these conditions, overlooking the contribution of neurons.

Neuro-epithelial circuits promote sensory convergence and intestinal immunity

Type 2 inflammation at barrier surfaces is an evolutionarily conserved response that promotes immunity to helminth parasites, allergic inflammation and tissue repair1–4. Direct sensing of environmental triggers by epithelial cells initiates type 2 inflammation, and signals derived from neurons can modulate immune responses5–8. However, how diverse sensory inputs from epithelial, neuronal and immune cells are coordinated and integrated remains un…

Neuro-Epithelial Circuit Identified in Gut Linking TRPV1+ Nociceptors and Tuft Cells to Intestinal Immunity Regulation

Researchers have identified a neuro-epithelial circuit […] The post Neuro-Epithelial Circuit Identified in Gut Linking TRPV1+ Nociceptors and Tuft Cells to Intestinal Immunity Regulation first appeared on GeneOnline News. The post Neuro-Epithelial Circuit Identified in Gut Linking TRPV1+ Nociceptors and Tuft Cells to Intestinal Immunity Regulation appeared first on GeneOnline News.

Neuro-Epithelial Circuits Boost Gut Immunity

In a remarkable leap forward for immunology and neurobiology, new research has uncovered a groundbreaking neuro-epithelial circuit that orchestrates intestinal immunity through the sensory convergence of pain-sensing neurons and specialized epithelial cells. This discovery unveils an intricate dialogue between TRPV1^+ nociceptors—neurons traditionally associated with pain perception—and chemosensory tuft cells in the gut, serving as a […]