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Ozempic-like drug significantly reduces frequency of chronic migraines in pilot study

  • Italian researcher Simone Braca and colleagues conducted a 12-week pilot study testing liraglutide on 31 obese patients with chronic migraines.
  • The study arose because many migraine sufferers do not find relief with existing drugs and obesity is linked to increased migraine risk.
  • Participants experienced an average reduction in migraine days from around 20 to 11 per month and one patient became completely migraine-free.
  • The side effects like nausea and constipation were mild and resolved during the study, while researchers propose liraglutide reduced intracranial pressure causing symptom relief.
  • Though preliminary and lacking a control group, the findings suggest GLP-1 receptor agonists could become valuable add-ons for difficult migraine cases, pending further research.
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Gizmodo broke the news in United States on Monday, June 30, 2025.
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