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Opportunities in IgA Nephropathy Research: Exploring the 4 Hit Process
- IgA nephropathy is a progressive autoimmune kidney disease that typically affects adults aged 20 to 40 worldwide.
- The disease develops as immune complexes formed with Gd-IgA1 build up within the kidneys, resulting in damage that can ultimately lead to kidney failure.
- Symptoms vary and may include hematuria, proteinuria, fatigue, and high blood pressure, with early stages often asymptomatic or subtle, delaying diagnosis.
- Research efforts focus on targeting APRIL and the 4 hit process as potential therapeutic strategies, supported by Otsuka's commitment to advanced kidney disease treatments.
- Many patients progress to end-stage kidney disease, emphasizing the need for continued research and patient support to improve management and outcomes.
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Biomarker Points to Anti-Inflammatory Action of Sparsentan
(MedPage Today) -- Early findings from the SPARTAN phase II trial, presented at the National Kidney Foundation (NKF) Spring Clinical Meeting, suggested that benefits with sparsentan (Filspari) for immunoglobulin A (IgA) nephropathy extend beyond...
·New York, United States
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Opportunities in IgA Nephropathy Research: Exploring the 4 Hit Process
(StatePoint) IgA nephropathy is a progressive, autoimmune, chronic disease that predominantly affects adults between the ages of 20 and 40, with an annual global incidence of 2.5 cases per 100,000 people. Despite its prevalence, IgA nephropathy remains a challenging disease…
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