Dire Wolves Lived in Indiana, but Should We Bring Them Back?
- Colossal Biosciences successfully revived the dire wolf by breeding two males in October 2024 and a female in January 2025.
- The project followed the dire wolf's disappearance from North America about 13,000 years ago, using advanced DNA and gene-editing techniques.
- The process combined ancient DNA from specimens up to 72,000 years old with genomic editing and reproductive technology to produce healthy dire wolf puppies.
- Ben Lamm, CEO of Colossal, explained that their team extracted genetic material from ancient remains dating back thousands of years—a tooth around 13 millennia old and a skull approximately 72 millennia old—to successfully create healthy dire wolf pups.
- This achievement marks a historic moment in de-extinction science, signaling potential advances in conservation and biotech with plans to revive species like the woolly mammoth by 2028.
10 Articles
10 Articles

Dire wolves lived in Indiana, but should we bring them back?
A biotechnology company's recent announcement that it had revived a wolf species that went extinct 10,000 years ago is both generating excitement and raising questions about efforts to conserve wild animal populations and the environment.
The Remarkable Journey of Colossal's De-Extinct Dire Wolves
In a scientific achievement that reads like science fiction made real, Colossal Biosciences has accomplished what many thought impossible: successfully bringing back the dire wolf (Aenocyon dirus), an apex predator that disappeared from North America approximately 13,000 years ago. While many are familiar with dire wolves from popular culture like “Game of Thrones,” few realize these were once real creatures that dominated the American landscape…
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