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Clinical Trial Finds Single-Dose Penicillin Effective Against Syphilis
A trial involving 249 participants showed 76% response rate to single-dose benzathine penicillin G, matching three-dose efficacy and easing treatment burden amid rising syphilis cases.
- A late-stage clinical trial reported that a single dose of benzathine penicillin G 2.4 MU matches three-dose efficacy for early syphilis, as published in the New England Journal of Medicine.
- Rising U.S. syphilis rates and recurring BPG shortages prompted a trial as the United States recorded more than 209,000 syphilis cases in 2023, a 61% increase from 2019.
- Enrolling 249 people across 10 U.S. sites, the trial showed 97% men and 61% people living with HIV with serologic response rates of 76% versus 70%, a non-significant difference.
- Safety data showed no serious adverse events attributable to benzathine penicillin G , and a one-dose regimen could reduce visits, improve patient engagement, and limit antibiotic stock and resistance concerns.
- Researchers note more study is needed to determine one-dose effectiveness for late-stage syphilis, latent syphilis of unknown duration, and neurosyphilis, while broader adoption could lessen syphilis's burden on healthcare systems globally.
16 Articles
16 Articles
The Laconia Daily Sun
Single-Dose Penicillin Effective Against Early Syphilis
Key Takeaways
Single penicillin injection found to be as effective as three doses for early syphilis
Researchers funded by the National Institutes of Health (NIH) have found that a single injection of the antibiotic benzathine penicillin G (BPG) successfully treated early syphilis just as well as the three-injection regimen used by many clinicians in the United States and elsewhere.
One dose of antibiotic treats early syphilis as well as three doses, clinical trial shows
Researchers have found that a single injection of the antibiotic benzathine penicillin G (BPG) successfully treated early syphilis just as well as the three-injection regimen used by many clinicians in the United States and elsewhere. These findings from a late-stage clinical trial suggest the second and third doses of conventional BPG therapy do not provide a health benefit.
Single Antibiotic Dose as Effective as Three for Treating Early Syphilis,
In a groundbreaking advancement in the treatment of early syphilis, researchers funded by the National Institutes of Health (NIH) have demonstrated that a single dose of the antibiotic benzathine penicillin G (BPG) is as effective as the traditional three-dose regimen widely prescribed across clinical settings. This pivotal finding, emerging from a rigorously controlled late-stage clinical trial, offers a compelling opportunity to simplify syphi…
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