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Once-a-Day Pill Cuts 10pc of Your Body Weight and Is Cheaper than Jabs

Orforglipron showed an average weight loss of 9.6% in a 72-week phase 3 trial involving 1,613 people with obesity and type 2 diabetes, offering a convenient oral alternative to injectables.

  • Adults with obesity and type 2 diabetes who took the oral GLP-1 agonist orforglipron along with lifestyle changes lost significantly more weight than those on placebo over 72 weeks.
  • The highest 36mg dose of orforglipron led to an average 9.6% body weight loss, and weight loss was accompanied by reductions in blood glucose levels.
  • Researchers suggest orforglipron could provide a convenient oral treatment option similar to injectable GLP-1 agonists, potentially shifting treatment paradigms.
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Wales Online broke the news in Wales, United Kingdom on Thursday, November 20, 2025.
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