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Oldest known plague outbreak occurred in Siberia 5,500 years ago, study finds
Researchers found plague DNA in 18 of 46 hunter-gatherers, showing the disease caused two outbreaks and likely spread through marmots and person-to-person contact.
On Wednesday, researchers published findings in Nature revealing the oldest known plague outbreaks, dating back about 5,500 years among hunter-gatherers buried near Lake Baikal, Siberia.
This discovery challenges long-standing theories that deadly epidemics required Neolithic farming or high-density settlements, showing plague emerged long before agricultural lifestyles became widespread.
Genetic analysis of 42 hunter-gatherers revealed Yersinia pestis DNA in 18 remains, with researchers identifying marmots as the likely animal reservoir triggering infections that particularly impacted children.
Evidence of acute mortality and mass burials indicates rapid transmission; University of Oxford geneticist Ruairidh Macleod called the findings a "devastating outbreak" affecting entire communities.
These genomes capture plague near its evolutionary origin, pushing back the split between Y. pestis and Y. pseudotuberculosis by about 2,000 years and revealing previously unknown bacterial diversity.