Nanoparticles Overcome Drug-Resistant Cancer via Sequential Drug Release and Photothermal Therapy

Nanoparticles overcome drug-resistant cancer via sequential drug release and photothermal therapy

Cancer cells frequently develop the ability to expel anticancer drugs before they can work—a phenomenon called multidrug resistance (MDR)—which is one of the leading reasons why chemotherapy fails in patients. Research published in the Journal of Controlled Release addresses that problem with a fundamentally new strategy: instead of simply increasing drug doses or switching drugs, researchers engineered nanoparticles that first disable the cance…

New nanoparticles disable drug resistance to achieve complete tumor elimination

Cancer cells frequently develop the ability to expel anticancer drugs before they can work -- a phenomenon called multidrug resistance (MDR) -- which is one of the leading reasons why chemotherapy fails in patients.

Nanoparticles Combat Drug-Resistant Cancer Through Sequential Drug Delivery

In the relentless battle against cancer, one of the most daunting challenges has been the phenomenon of multidrug resistance (MDR), where cancer cells develop the ability to actively expel chemotherapeutic agents before these drugs can inflict their intended damage. This defense mechanism, primarily driven by the overexpression of P-glycoprotein (P-gp) pumps on the cancer cell […]

Nanoparticles Used for Sequential Drug Delivery and Photothermal Therapy to Combat Multidrug Resistance in Cancer Cells Overexpressing P-gp Pumps

Researchers are exploring a novel approach to combat mu […] The post Nanoparticles Used for Sequential Drug Delivery and Photothermal Therapy to Combat Multidrug Resistance in Cancer Cells Overexpressing P-gp Pumps first appeared on GeneOnline News. The post Nanoparticles Used for Sequential Drug Delivery and Photothermal Therapy to Combat Multidrug Resistance in Cancer Cells Overexpressing P-gp Pumps appeared first on GeneOnline News.

Nanoparticles that disable drug resistance before delivering chemo eliminate tumors in mice

A two-step nanoparticle system first blocks cancer cells' drug-expulsion mechanism, then releases chemotherapy combined with laser-driven heat to destroy resistant tumors.