New method generates renewable supply of progenitor immune cells
The method lets GMPs self-renew and be engineered with CARs, and the cells delayed cancer in mice while restoring infection-fighting ability in another model.
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3 Articles
A renewable cell source for cancer immunotherapy could make off-the-shelf treatments possible
In a paper published in Cell, a USC Stem Cell-led team reports a new way of generating a renewable and expandable supply of the progenitor cells that give rise to macrophages. These immune cells help drive the body's response against pathogens, and they hold strong promise as the basis for immunotherapies against cancer and other diseases.
USC Stem Cell-led team creates a renewable cell source for cancer immunotherapy and beyond - USC Stem Cell
In a paper published in Cell, a USC Stem Cell-led team reports a new way of generating a renewable and expandable supply of the progenitor cells that give rise to macrophages. These immune cells help drive the body’s response against pathogens, and they hold strong promise as the basis for immunotherapies against cancer and other diseases. The paper demonstrates that progenitor cells known as granulocyte-monocyte progenitors (GMPs), which give r…
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