New insights into neuron–microglia interactions during brain aging

New insights into neuron–microglia interactions during brain aging

Researchers at the University of Tsukuba have identified small nuclear fragments known as micronuclei while studying neurons in aged mice. They demonstrated that microglia—the brain's resident immune cells—take up these micronuclei, leading to changes in microglial morphology and gene expression associated with inflammation and vascular function. The research is published in the journal Frontiers in Aging Neuroscience.