New Gene Editing Tool Reduces Huntington's Symptoms in Mice

Gene editing tool reduces Huntington's toxic protein fragments and symptoms in mice

A gene-editing tool designed to precisely rewrite the gene that causes Huntington's disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.

New gene editing tool reduces Huntington's symptoms in mice

A gene editing tool designed to precisely rewrite the gene that causes Huntington's disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.

Rewriting Disease: Gene Editing Breakthroughs in Hawaii

Imagine being able to edit disease out of a person's DNA.

Pkhd1 Gene Deletion Linked to Reduced Tfap2b Expression and Eye Abnormalities in Mice

Researchers have identified a link between the deletion of the *Pkhd1* gene and the development of eye abnormalities in mice, according to a study published in *Nature Communications*. The findings indicate that the absence of this gene, which is associated with Autosomal Recessive Polycystic Kidney Disease (ARPKD), leads to a measurable decrease in the expression

Base Editing Strategy Alleviates Huntington’s Disease in Mice

According to at least one estimate, approximately 41,000 people in the United States have symptoms of Huntington’s disease, and more than 200,000 are at-risk of inheriting the disease. Symptoms of the neurodegenerative disorder, which is caused by a CAG expansion within exon 1 of the huntingtin gene, include personality changes, unsteady gait and involuntary movements, slurred speech, and more. Currently, there are multiple efforts underway to d…