New compound shows promise against aromatase inhibitor-resistant breast cancer

New compound shows promise against aromatase inhibitor-resistant breast cancer

A new research paper was published in Volume 16 of Oncotarget on July 29, 2025, titled "PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion."

New Compound Targets Survival Mechanisms in Aromatase Inhibitor-Resistant

A groundbreaking study published in the latest volume of Oncotarget illuminates a promising new frontier in the fight against breast cancer, particularly focusing on cases resistant to aromatase inhibitor (AI) therapy. AI resistance — a notorious clinical challenge — often leaves patients with limited treatment options once standard endocrine therapies fail. This innovative research introduces […]