Autophagy and Lysosomal Pathways Orchestrate Unconventional Secretion of Parkinson's Disease Protein

Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are bound for secretion harbor an N-terminal signal peptide that guides their movement from the endoplasmic reticulum (ER) and Golgi apparatus to the exterior of the cell.

Autophagy and Lysosomal Pathways Drive Unconventional Secretion of

A groundbreaking revelation from researchers at Doshisha University, Japan, has unveiled an extraordinary mechanism underlying the unconventional secretion of PARK7—a protein intricately linked to Parkinson’s disease and cellular oxidative stress responses. This new study illuminates how the interplay between two forms of autophagy, typically regarded as cellular degradation pathways, orchestrates a secretory process divergent from classical pro…

Sensors, machine learning aid in ID'ing Parkinson's-like movement...

Integrating movement sensors and machine learning approaches may aid a correct diagnosis of movement disorders, including essential tremor and myoclonus, a study in the Netherlands suggests. Essential tremor is a progressive movement disorder marked by tremors, while myoclonus refers to brief, shock-like muscle jerks. Both can occur during voluntary movements and may resemble motor symptoms seen in Parkinson’s disease, making them challenging to…

Parkinson's disease is a neurodegenerative disease, which is diagnosed mainly on the basis of clinical symptoms, especially motor disorders, in the late stages. Then, however, the brain is already massively and irreparably damaged. Moreover, the diagnosis is difficult and often f...