US EditionHeart Attacks Are Less Harmful at Night. And that Might Be Key to Treating Them.
The CXCR4 agonist ATI2341 reduces heart attack tissue damage by keeping neutrophils in a less aggressive nighttime state, protecting heart function in mice and aligning with human data.
6 Articles
6 Articles
Scientists have developed a pharmacological strategy that seeks to keep neutrophils in a "nightly" state during a heart attack.
Suffering a myocardial infarction is always a medical emergency.However, new scientific evidence indicates that the time of the day when it occurs can influence the magnitude of the damage to the heart.Spanish researchers identified a biological mechanism that explains why nocturnal cells tend to be less severe than those that occur during the day.The key is in neutrophils, a type of white blood cell that is fundamental in the immune response.Th…
To suffer from myocardial infarction is always a medical emergency. However, new scientific evidence indicates that the time of the day in which it occurs can influence the magnitude of the damage to the heart. Spanish researchers have identified a biological mechanism that explains why nightly infarctions tend to be less serious than those that occur during the day. The key is in neutrophils, a type of basic white globe in the immunological res…
In addition, researchers developed a pharmacological strategy in experimental models to block the molecular clock of these cells, keeping them in a “nightly” state and thus reducing their harmful potential during the infarction. The immune system protects the body from microorganisms that can cause infections. Since humans are a daytime species, the probability of exposure to pathogens is greater during the day. Therefore, the immune system adju…
Keeping Neutrophils in Night Mode Could Reduce Post-Heart Attack Inflammation
Heart attacks that occur at night are less severe than those that strike during the day. A new study headed by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and at Yale University School of Medicine, has explained why. Andrés Hidalgo, PhD and colleagues found that neutrophils have an internal clock that regulates their aggressiveness throughout the day and determines the extent of damage they cause to the heart af…
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