Nerves and Fibroblasts Form Early Alliance in Pancreatic Cancer

Nerves and Fibroblasts Form Early Alliance in Pancreatic Cancer

A new study is reshaping how researchers think about the earliest steps of pancreatic cancer progression, revealing that sympathetic nerves and cancer-associated fibroblasts collaborate far earlier than expected to fuel disease growth. In work published in Cancer Discovery, investigators from Cold Spring Harbor Laboratory and colleagues show that in pancreatic ductal adenocarcinoma (PDAC), dense sympathetic nerve infiltration is already present …