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A New Lyme Disease Vaccine Could Soon Be Available for Humans

The vaccine was well tolerated and showed more than 70% efficacy in people ages 5 and older, with no safety concerns identified.

  • Pfizer and Valneva shared last week that their vaccine VALOR, short for "Vaccine Against Lyme for Outdoor Recreationists," demonstrated more than 70% efficacy in preventing Lyme disease in individuals ages five and older.
  • Lyme disease is a bacterial infection spread by blacklegged ticks, causing fever, fatigue, and characteristic rashes; the CDC estimates as many as 476,000 people are diagnosed and treated annually in the U.S.
  • The drugmaker reported the vaccine was well tolerated with no safety concerns identified at the time of analysis, while most cases of Lyme disease are currently treated successfully with antibiotics.
  • No vaccines to prevent Lyme disease are currently available for humans, though regulatory approval from the Food and Drug Administration could change that if granted to the companies.
  • Lyme disease is most common in the Northeast and named after Lyme, Connecticut, where it was first discovered in 1975, though a previous vaccine approved in 1998 was pulled from the market in 2002.
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Scientific American broke the news in on Monday, March 30, 2026.
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