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US Open 2025: Jannik Sinner vs Lorenzo Musetti Preview, Head-to-Head, Odds, Prediction, and Pick

On September 3, 2025, Jannik Sinner meets Lorenzo Musetti in a US Open quarterfinal at Arthur Ashe Stadium, continuing his quest for a second straight title.
Musetti, meanwhile, has regained form at the US Open tournament in New York, dropping one set through his first four matches and holding a 26-12 season record.
The scheduled start time shifted to 6:30 AM IST from the original 5:40 AM start time due to earlier matches running late, with live US Open coverage on ESPN and ESPN+ in the USA and Sky Sports in the UK; the tournament features $90,000,000 prize money.
The victor advances to the US Open semifinals, with Sinner viewed as a heavy betting favorite expected to face little adversity reaching the final four.
Their head-to-head record shows Jannik Sinner leads 2-0, winning in Monte Carlo 2023 and Antwerp 2021, while Lorenzo Musetti's recent serve alterations could impact their match.

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