How a Multiple Sclerosis Drug Reshapes the Immune System

Real-world evidence of ocrelizumab-treated relapsing multiple sclerosis cohort shows changes in progression independent of relapse activity mirroring phase 3 trials

Ocrelizumab is a B cell-depleting drug widely used in relapsing–remitting multiple sclerosis (RRMS) and primary-progressive MS. In RRMS, it is becoming increasingly apparent that accumulation of disability not only manifests as relapse-associated worsening (RAW) but also as progression independent of relapse activity (PIRA) throughout the disease course. This study’s objective was to investigate the role of PIRA in RRMS patients treated with ocr…

How a multiple sclerosis drug reshapes the immune system

When ocrelizumab became the first FDA-approved treatment for early forms of multiple sclerosis (MS) in 2017, it offered patients immense hope. The long-awaited drug is a monoclonal antibody that depletes B cells—the immune cells that drive MS progression. Exactly how ocrelizumab does this, however, remains unclear.

Multiple Sclerosis Drug Reshapes the Immune System

The breakthrough drug ocrelizumab has an unexpected effect on T cells that could shed light on how multiple sclerosis begins.

Georgia Expands MS Care with Free Drugs and Services

Tbilisi, Georgia: The government of the country has expanded its rare disease program to support multiple sclerosis patients with free medicines, MRI scans, and medical services, helping improve treatment and reduce family expenses. The Minister of Health of Georgia met with patients diagnosed with multiple sclerosis and their family members – about state funding and new services, Mikheil Sarjveladze, gave them detailed information. According to…

B cell depletion changes the immune cell profile in multiple sclerosis patients: One-year report

MS quiet progression: Expert discusses new research, treatment

Scientists have made significant advances in treating multiple sclerosis (MS) in recent decades, with a number of treatments for the neurodegenerative disease approved or in development. According to researchers, however, […] The post MS quiet progression: Expert discusses new research, treatment appeared first on Multiple Sclerosis News Today.