Organoid Co-Cultures Expose Epithelial and Fibroblast Diversity In

Organoid co-cultures expose epithelial and fibroblast diversity in

Pancreatic cancer has long been one of the most formidable opponents in oncology, and a substantial part of its lethality lies not in the cancer cells themselves but in the tissue that surrounds them. Now, a team of researchers has built an intricate laboratory model that recreates the dense, fibrous environment enveloping pancreatic tumors

Multi-Stromal Organoid Co-Culture Modelling Reveals Epithelial-Fibroblast Heterogeneity in Pancreatic Cancer and Pancreatitis

Researchers compared fibroblast diversity and epithelial–stromal interactions in pancreatitis and PDAC using human samples, mouse models, and mouse pancreatitis-derived epithelial organoids. [Nature Cell Biology] Full Article