APOE Gene: A Major Driver in Alzheimer's Disease

Without This One Gene, Up To 93 Percent Of Alzheimer’s Disease Cases Would Not Happen: "It Is A Natural Target"

Two variants in a single gene are implicated in almost all Alzheimer’s and nearly half of all dementia cases, according to new findings.

APOE gene: A major driver in Alzheimer's disease

Potentially more than 90% of Alzheimer's disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

Most Alzheimer’s cases linked to a single gene, study finds

One gene called APOE has long been known to increase the risk of Alzheimer’s disease, but without a specific variant most cases would not occur

APOE Gene May Be Responsible for Most Alzheimer's Disease

Researchers based at University College London claim that the ε3 and ε4 variants of the APOE gene are responsible for most cases of Alzheimer’s disease. As reported in npj Dementia, an analysis using individuals with two copies of the protective ε2 variant as a comparator, 71–93% of Alzheimer’s and cerebral amyloidosis was attributable to ε3 and ε4 and around 44% of dementia. “When we consider the contributions of ε3 and ε4, we can see that APOE…

Alzheimer's Risk May Be Driven by a Single Gene

(MedPage Today) — Most Alzheimer’s disease and nearly half of all dementia was associated with variations in the APOE gene, a study of 470,000 older adults suggested. In Alzheimer’s disease, APOE3 and APOE4 were tied to 71.5% to 92.7% of cases… Source link : https://www.medpagetoday.com/neurology/alzheimersdisease/119357 Author : Publish date : 2026-01-09 17:04:00 Copyright for syndicated […] The post Alzheimer’s Risk May Be Driven by a Single G…