Microbiota-driven antitumour immunity mediated by dendritic cell migration

Microbiota-driven antitumour immunity mediated by dendritic cell migration

Gut microbiota influence the antitumour efficacy of immune checkpoint blockade1–6, but the mechanisms of action have not been fully elucidated. Here, we show that a new strain of the bacterial genus Hominenteromicrobium (designated YB328) isolated from the faeces of patients who responded to programmed cell death 1 (PD-1) blockade augmented antitumour responses in mice. YB328 activated tumour-specific CD8+ T cells through the stimulation of CD10…

Microbiota-driven Antitumour Immunity Mediated By Dendritic Cell Migration - Data Intelligence

Patients with advanced NSCLC (n = 22) and patients with GC (n = 49) who received PD-1 blockade monotherapy (nivolumab or pembrolizumab) from March 2017 to

Microbiota Boosts Tumor Immunity via Dendritic Cells

A groundbreaking study published in Nature in 2025 unveils how specific gut microbiota can dramatically influence the maturation of dendritic cells, thereby orchestrating robust antitumour immunity. Researchers have pinpointed a novel bacterial strain, YB328, which outperforms conventional strains like Parabacteroides vulgatus in activating and reprogramming bone-marrow-derived dendritic cells (BMDCs), pivotal players in immune surveillance and …