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Inherited EGFR Mutation Raises Lung Cancer Risk in Nonsmokers
The variant was tied to a 25.2-fold higher lung cancer risk overall and a 61.7-fold increase in nonsmokers, researchers reported.
- Researchers reported in Science on September 24, 2026, that a rare inherited EGFR T790M variant increases lung cancer risk 25.2-fold, making it one of the strongest known genetic risk factors for any cancer.
- Analyzing data from nearly 3.4 million people, study co-lead Jaclyn LoPiccolo, MD, PhD, of Dana-Farber Cancer Institute found the mutation confers a 61.7-fold higher risk for nonsmokers and a 10.6-fold increase for smokers.
- The variant's effect exceeds established BRCA1 and BRCA2 breast cancer risks and smoking's 3.8-fold risk. Researchers observed no significant associations between T790M and 17 other non-lung cancers.
- Dr. John A. D'Orazio, M.D., Ph.D., at Golisano Children's at UK notes that genetic knowledge enables personalized, proactive care plans. Clinical experts aim to incorporate findings into computed tomography screening guidelines.
- The INHERIT study seeks to validate these findings for broad clinical use, shifting from reactive treatment to proactive monitoring and detection at the most curable, early stages.
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Rare Genetic Mutation Linked To 25-Fold Higher Lung Cancer Risk
·Jersey City, United States
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Never smoked a cigarette? You could still be at higher risk for lung cancer - NEW YORK TIMES POST
NEWYou can now listen to Fox News articles! A rare genetic mutation could put people at a dramatically higher risk of developing lung cancer – even if they’ve never smoked. A rare mutation in the gene EGFR T790M was found to increase lung cancer risk by 25 times compared with people who did not have [...]
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