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LP(a) screening may help detect inherited heart disease risk
The test can identify an inherited risk factor in 20% to 25% of people and is now recommended once in a lifetime.
- The American College of Cardiology and American Heart Association released 2026 guidelines recommending everyone receive at least one lifetime lipoprotein test to identify hidden risks for heart attacks and strokes.
- Approximately 20 to 25% of people have elevated lipoprotein levels, which are almost entirely inherited and remain stable throughout life; unlike standard cholesterol panels, this particle is not routinely screened.
- Shep Joseph of Allison Park, Pennsylvania, required bypass surgery and 11 stents after missing an LP diagnosis at age 54, urging proactive testing: "You just have to take it once."
- Insurance coverage varies; Aetna and UPMC Health Plan have updated policies to align with guidelines, while Labcorp and Quest Diagnostics offer the test for about $50 without coverage.
- Drugs designed to lower lipoprotein are now in phase 3 clinical trials, and Doctor Indu Poornima notes that controlling LDL levels below 70 can reduce risk from elevated lipoprotein.
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