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Low-dose megestrol strengthens hormone therapy in ER-positive breast cancer

The PIONEER trial showed low-dose megestrol acetate combined with letrozole reduced tumor proliferation markers by 30% and increased Ki67 ≤10% responses to 80%.

Summary by News Medical
Low-dose megestrol enhances hormone therapy for ER-positive breast cancer, reducing tumor proliferation and improving treatment adherence in the PIONEER trial.

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News Medical broke the news in United States on Wednesday, January 7, 2026.
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