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Loss of protein in ALS silences key nerve cell communication gene
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Loss of protein in ALS silences key nerve cell communication gene
In amyotrophic lateral sclerosis (ALS), the loss of any one of four RNA-binding proteins turns off a gene called UNC13A that needs to stay active for nerve cells to communicate with each other — with three of them leading to an excess of another protein, REST — pointing to a new avenue for treatment. That’s according to a new study by researchers in Japan, the findings of which highlight the key role of UNC13A in ALS development, per the team. “…
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