US Edition
Long-term antidepressant use linked to higher risk of withdrawal symptoms
- A 2025 UCL-led study surveyed 310 antidepressant users in England who attempted to stop the medication and found long-term use linked to higher withdrawal risks.
- This research built on background concerns that long-term antidepressant use often causes withdrawal symptoms, complicating discontinuation especially beyond two years of use.
- The study reported that 79% of people on antidepressants for two or more years experienced withdrawal and were less able to stop, with symptoms ranging from dizziness to mood worsening.
- Lead author Dr. Mark Horowitz explained that the risk of withdrawal symptoms when stopping antidepressants depends mainly on how long they have been taken, and he advised exercising caution with extended use.
- The findings suggest clinicians should inform and closely monitor patients when discontinuing antidepressants and develop individualized tapering plans to reduce withdrawal impact.
11 Articles
11 Articles
Withdrawal symptoms are common after stopping antidepressants
A new study published in Molecular Psychiatry estimates that about 43% of people who stop taking antidepressants experience withdrawal symptoms. These symptoms typically appear within two weeks of stopping the medication and can range from mild to severe. The findings suggest that withdrawal effects are widespread and highlight the need for better guidance on how to discontinue antidepressants safely. Antidepressants are some of the most widely …
Antidepressant withdrawal symptoms more common among long-term users, study finds
People who have been taking antidepressants for more than two years are substantially more likely to experience withdrawal symptoms compared to short-term users when they come off the medication, finds a new study led by UCL researchers.
Long-term antidepressant use linked to higher risk of withdrawal symptoms
People who have been taking antidepressants for more than two years are substantially more likely to experience withdrawal symptoms compared to short-term users when they come off the medication, finds a new study led by UCL researchers.
Antidepressants withdrawal effects and duration of use: a survey of patients enrolled in primary care psychotherapy services
Previous studies of antidepressant withdrawal have been limited by short duration of drug exposure or self-selected samples. Our study aimed to estima…
Coverage Details
Bias Distribution
- 75% of the sources are Center
To view factuality data please Upgrade to Premium
Ownership
To view ownership data please Upgrade to Vantage
