Stem cell therapy frees diabetics from insulin

Benton Elementary student to advocate for diabetes research in Children’s Congress

Eli Jackson was in elementary school when he was first diagnosed with Type 1 Diabetes. Now, he and his mother Cheryl Jackson will be traveling to Washington, D.C. in July, where Eli will participate in the Breakthrough T1D Children’s Congress.

People with severe diabetes cured in small stem cell trial

A man having his continuous glucose monitor checked by his doctor. Halfpoint/ShutterstockThe cure for diabetes is a life free from daily insulin injections. Based on that criterion, ten out of 12 people (83%) in a new clinical trial were cured of their diabetes one year after receiving an advanced stem cell therapy. This study used laboratory-grown pancreatic islet cells. They were infused into the liver, where they took up residence. Within a y…

New pretreatment method boosts islet transplant survival in diabetes

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

Insulin neoantigen elicits memory T cell activation in diabetes

A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T cell activation and memory responses.

This Stem Cell Treatment Could One Day Make Insulin Obsolete

Type I diabetes is an exhausting full-time job. Having it means living a life full of constant care and maintenance. You’re always checking in on your blood sugar to make sure it isn’t too high or is it too low, extremes that could be easily reached with the most minor indulgence or tiniest bout of laziness. A new treatment, as detailed in the New York Times, might change everything we know about managing type I diabetes. Zimislecel is an experi…

People With Severe Diabetes Are Cured in Small Trial of New Drug

single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of Type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much…