Lithium, a well-known treatment in psychiatry, is re-entering the Alzheimer’s debate with fresh mechanistic insight. In a new study published in Translational Psychiatry, researchers revisit whether lithium could help preserve cognition in Alzheimer’s disease—and, crucially, explore how its effects may depend on the brain’s cholinergic circuitry and large-scale connectivity. The work centers on the cholinergic system, which relies on acetylcholi…
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