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Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The model projects 58 combined points and says the Over has value in 57% of simulations.

Summary by CBS Sports
The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game
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5 Articles

NBC SportsNBC Sports
Center

Bills vs Lions Odds, expert picks, team and player news, betting trends, and stats

Buffalo Bills vs Detroit Lions Game Preview

·Stamford, United States
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Sports IllustratedSports Illustrated
Lean Left

Lions vs. Bills Score Prediction for NFL Week 2 (Expect a Ton of Points on Thursday Night)

Using the latest odds and analysis to predict the final score of the Detroit Lions-Buffalo Bills matchup in Week 2 of the NFL season.

·New York, United States
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CBS SportsCBS Sports
Center

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game

·Fort Lauderdale, United States
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USA TodayUSA Today
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AZCentralAZCentral
Lean Left

Lions vs Bills odds, point spread, moneyline, total for game Thursday

Buffalo Bills vs Detroit Lions odds for NFL Week 2 game betting, including point spread, moneyline, over/under, total for Thursday, Sept. 17, 2026.

·New York, United States
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Bias Distribution

  • 60% of the sources lean Left
60% Left

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USA Today broke the news in New York, United States on Wednesday, September 16, 2026.
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