LINE-1 elements found essential for early embryonic development

LINE-1 elements found essential for early embryonic development

A new review from Genes and Diseases sheds light on the pivotal role of LINE-1 elements in preimplantation development and totipotency, revealing their essential contributions to early mammalian embryogenesis.

Revealing the Crucial Role of LINE-1 in Early Embryo Development

A groundbreaking review published in the journal Genes & Diseases has unveiled transformative insights into the multifaceted role of LINE-1 (Long Interspersed Nuclear Element-1) retrotransposons in preimplantation development and the maintenance of totipotency in mammalian embryos. For decades, LINE-1 elements were largely dismissed as dormant genomic parasites or evolutionary fossils, but recent research now categorically positions them as cent…