Sequence Diversity Lost in Early Pregnancy

Sequence diversity lost in early pregnancy

Every generation, the human genome is shuffled during meiosis and a single fertilized egg gives rise to all of the cells of the body1. Meiotic errors leading to chromosomal abnormalities are known causes of pregnancy loss2,3, but genetic aetiologies of euploid pregnancy loss remain largely unexplained4. Here we characterize sequence diversity in early pregnancy loss through whole-genome sequencing of 1,007 fetal samples and 934 parental samples …

Lethal mutations in pregnancy loss

REYKJAVIK, Iceland, May 21, 2025 /PRNewswire/ -- In a study published in Nature today "Sequence diversity lost in early pregnancy," scientists from deCODE genetics, a subsidiary of Amgen, estimate that around one in 136 pregnancies are lost due to...

REYKJAVIK, Iceland, May 21, 2025 /PRNewswire/ — In a study published today in the journal Nature, titled "Sequence Diversity Lost in Early Pregnancy," scientists at deCODE genetics, a subsidiary of Amgen, estimate that approximately one in 136 pregnancies results in miscarriage due to the presence of new genetic mutations in the fetus. In other words, millions of pregnancies around the world are aborted every year due to genetic mutations. The h…