US EditionNew Three-Pronged Blood Test Predicts Heart Attack Risk
A UK Biobank study found participants with elevated levels of three biomarkers had nearly triple the heart attack risk over 15 years, aiding earlier detection.
- On Nov. 7, researchers presented a preliminary study at the American Heart Association Scientific Sessions 2025 analyzing health data from 306,183 adults in the UK Biobank who were free of heart disease at enrollment.
- Researchers measured three biomarkers—lipoprotein, remnant cholesterol, and hsCRP—simultaneously at baseline and counted how many were in the top 20% threshold, adjusting for conventional cardiovascular risk factors.
- Data show a stepwise pattern where participants with all three elevated biomarkers had nearly triple the heart attack risk, two-elevated had more than double, and one-elevated had about a 45% higher risk.
- The findings could help health care professionals detect heart disease risk earlier and guide preventive therapies, but researchers note evidence is needed to confirm improved outcomes, Kazibwe said.
- As an observational study, the research shows patterns but cannot prove causation, and additional research is needed to confirm results in diverse populations while integrating hsCRP, remnant cholesterol, genetic scores, and coronary artery calcium scans.
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Three-Pronged Blood Test Highlights Heart Attack Risk
Key Takeaways
Analyzing 3 biomarker tests together may help identify high heart disease risk earlier
A combined analysis of blood tests to measure three biomarkers linked to higher risk of cardiovascular disease—lipoprotein a (Lp(a)), remnant cholesterol and high-sensitivity C-reactive protein (hsCRP)—may help identify high-risk individuals earlier and guide more personalized prevention strategies, according to a preliminary study presented at the American Heart Association's Scientific Sessions 2025, held Nov. 7–10, in New Orleans.
High Levels of Three Biomarkers Triples Risk for Heart Attack – RamaOnHealthcare
A combination of high levels of lipoprotein (Lp) a, remnant cholesterol and high-sensitivity C-reactive protein (CRP) significantly increases a person’s risk of heart attack according to new research.“Each of the blood tests on its own indicate only a modest increase in heart attack risk, however, when we found elevated levels for all three, the risk [...]
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