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Angiography-Guided PCI Assessment Confers Similar Outcomes to FFR for Intermediate Lesions
The ALL-RISE trial showed CathWorks FFRangio matches invasive pressure wire for one-year major cardiac events with 6.9% event rate and shorter procedure time.
- On Sunday, March 29, 2026, researchers presented ALL-RISE Trial results at the American College of Cardiology Scientific Session in New Orleans, showing the CathWorks FFRangio system is non-inferior to invasive pressure wire guidance for evaluating coronary lesions.
- Historically, interventionists evaluated coronary lesions by 'eyeballing' severity or using invasive pressure wires, said Dr. Ajay Kirtane; the AI-assisted FFRangio System now provides physiologic information from routine angiograms without requiring invasive wires.
- The randomized trial enrolled 1,930 patients, reporting no significant difference in primary endpoint events at one year: 6.9% for the FFRangio group versus 7.1% for the pressure wire group.
- Use of the FFRangio model reduced total contrast volume and procedure time compared to guidewire use, while patients experienced no increased risk of bleeding or acute kidney injury.
- Dr. Anna Bortnick, chair-elect of the ACC Interventional Council, called the study a "glimpse of the future of the cath lab," while Medtronic executive Jason Weidman said the data affirm confidence in FFRangio as a new worldwide standard.
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Angiography-guided PCI assessment confers similar outcomes to FFR for intermediate lesions
NEW ORLEANS — In patients with intermediate coronary lesions, an angiography-guided percutaneous coronary intervention strategy was noninferior to a pressure wire-guided PCI strategy for CV outcomes at 1 year, new data show. The ALL-RISE trial, presented at the American College of Cardiology Scientific Session and simultaneously published in The New England Journal of Medicine, showed that
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