Microglia Reveal Sex-Specific Brain Recovery Mechanism After Ketamine Anesthesia
Researchers found that corticosterone activates microglia in female mice, triggering extracellular matrix breakdown and synaptic remodeling during ketamine recovery.
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9 Articles
Research finds that stress hormones orchestrate a brain response that allows females to recover before the effect of ketamine, according to a work with mice
The male and female brain recover differently from ketamine and one has more plasticity
Microglia reveal sex-specific brain recovery mechanism after ketamine anesthesia
During ketamine anesthesia, the brain's nerve cells fall silent—as consciousness returns, they begin to reconnect. For the first time, researchers at the Institute of Science and Technology Austria (ISTA) have shown that immune cells in the brain play a critical role in this process—with differences between female and male brains. The findings were published in Science Advances.
Ketamine boosts brain plasticity in female mice, but not male mice
Ketamine has long been known as a powerful anesthetic, but its influence on the brain extends far beyond the operating room. Doctors also use low doses of the drug to manage pain and, more recently, to help people with treatment-resistant depression. Now, a study published in Science Advances suggests that ketamine can trigger profoundly different […]
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