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Jamie-Lynn Sigler Opens up About Playing 'Grey's Anatomy' Character with MS

Jamie-Lynn Sigler integrates her real-life MS journey into her character Dr. Laura Kaplan, highlighting empowerment and authentic representation in Grey's Anatomy's episode 2208.

  • On Thursday, Jamie-Lynn Sigler guest-stars as Dr. Laura Kaplan, a urologist with MS, in ABC's 2208 'Heavy on Me,' streaming now on Hulu and Disney+.
  • Because she feared career fallout, Sigler kept her MS private for 15 years before taking a role that reflects her experience, developed by Grey's Anatomy creative team almost a year ago.
  • The scene where Sigler says 'I have MS' was emotionally charged for her, marking her first substantive portrayal of the condition while Dr. Laura Kaplan urges a risky surgery for Dr. Richard Webber, patient in the episode.
  • Sigler said she hopes the role will inspire viewers and broaden representation, arguing with the Grey's Anatomy team that showing an accomplished physician with MS challenges stigma.
  • After a multi-year break, Jamie-Lynn Sigler is returning to TV and leaving the door open for more Grey's Anatomy appearances, saying this year she is stepping into her authenticity.
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Jamie-Lynn Sigler opens up about playing 'Grey's Anatomy' character with MS

Actress Jamie Lynn Sigler is opening up about taking on a meaningful new role nearly 25 years after she was diagnosed with multiple sclerosis.

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For Jamie-Lynn Sigler: In the series "Grey's Anatomy" the actress, who was ill with MS, appeared now as a doctor with MS.For Jamie-Lynn Sigler, 44, this moment felt like he was determined by fate.In a episode of "Grey's Anatomy" broadcast in the USA on January 15th, the actress Dr. Laura Kaplan - a respected urologist who, like Sigler, is himself ill with multiple sclerosis.It is the first time in her career that the 44-year-old plays a figure w…

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The Independent broke the news in London, United Kingdom on Thursday, January 15, 2026.
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