Isogenic Induced-Pluripotent-Stem-Cell-Derived Airway- and Alveolus-on-Chip Models Reveal Specific Innate Immune Responses

Isogenic Induced-Pluripotent-Stem-Cell-Derived Airway- and Alveolus-on-Chip Models Reveal Specific Innate Immune Responses

The authors developed human airway-on-chip and alveolus-on-chip models using lung progenitor cells derived from isogenic iPSCs. Using SARS-CoV-2 and influenza, they revealed distinct initial innate immune responses in the airway- and alveolus-on-chip models. [Nature Biomedical Engineering] Abstract